Candidate Gene Polymorphisms for Ischemic Stroke
نویسندگان
چکیده
منابع مشابه
Candidate gene polymorphisms for ischemic stroke.
BACKGROUND AND PURPOSE Ischemic stroke (IS) is a multifactorial disorder with strong evidence from twin, family, and animal model studies suggesting a genetic influence on risk and prognosis. Several candidate genes for IS have been proposed, but few have been replicated. We investigated the contribution of 67 candidate genes (369 single nucleotide polymorphisms [SNPs]) on the risk of IS in a N...
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BACKGROUND Contribution of cardiovascular disease related genetic risk factors for stroke are not clearly defined. We performed a genetic association study to assess the association of 56 previously characterized gene variants in 34 candidate genes from cardiovascular disease related biological pathways with ischemic stroke and cerebral hemorrhage in a Chinese population. METHODS There were 1...
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Broadly, strokes are classified into two main types-ischemic and hemorrhagic. Ischemic stroke (IS) is characterized by blockage in blood flow to a focal area of the brain, until hemorrhagic stroke is caused by bleeding into the brain. Acute IS is more common than hemorrhagic stroke. Although according the previous literature data about 80% of strokes were ischemic, the retrospective review from...
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OBJECTIVE Previous study suggested adiponectin receptor 2 (ADIPOR2) genetic polymorphisms were associated with the risk of ischemic stroke. However, the relation between adiponectin receptor 1 (ADIPOR1) gene polymorphism and stroke remains unclear. METHODS In the present study, we utilized the polymerase chain reaction-sequencing method to detect rs2275737 and s1342387 genotypes of ADIPOR1 ge...
متن کاملProtein Z gene polymorphisms, protein Z concentrations, and ischemic stroke.
BACKGROUND AND PURPOSE We aimed to determine whether A-13G or G79A polymorphisms of the protein Z gene that have been reported to be an important determinant of blood concentrations of protein Z are associated with risk of ischemic stroke in a broad range of stroke patients and controls. METHODS We conducted a case control study of 151 hospital cases of first-ever ischemic stroke and 164 rand...
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ژورنال
عنوان ژورنال: Stroke
سال: 2009
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.109.558015